Anti-leukemic assays on certain pyrimidines, purines, benzimidazoles, and related compounds.
نویسندگان
چکیده
supposed that genes control ultimately all cellular functions, including protein synthesis. From the close association of genes with nucleoproteins, it is natural to assume that nucleic acids may be in volved in protein synthesis. Such an assumption can be supported by the fact that nucleic acids are always found associated with self-duplicating units (e.g., genes, viruses, plastids, transforming prin cipals of pneumococci and coli)." Since, from a
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SYNTHESIS OF 4,4'-BIS-PYRIMIDINES AND SOME RELATED BIS-FUSED PYRIMIDINES
2,2'-Disubstitutedamino-4-4'-bis-pyrimidines (3a-m) have been prepared by linking 2,4-dichloro-6-methyl-5-nitropyrimidine (1) with several diamines and subsequent reaction with suitable amines. Some of these compounds (3c and 3j) which were reduced catalitically, on treatment with nitrous acid, urea in pyridine, and boiling thionyl chloride gave the corresponding bistriazolopyrimidin (6), ...
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In chemotherapeutic studies on various types of cancer, it has been observed that a few compounds related in structure to the purines and pyrimidines have a carcinolytic effect on certain tumors. It is of considerable interest to elucidate the mecha nisms by which these effects are produced. Toward this end investigations have been carried out in this laboratory on the effect of a purine analog...
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By Lw H. SMITH, JR., FArm A. BAKER AND MARGARET SULLIVAN I HE CENTRAL ROLE of ribonucleic acids and deoxyribonucleic acids in protein synthesis and genetic function, respectively, has led to a continued interest in their metabolism in neoplasia. A number of antineoplastic agents have been developed as structural analogs of purine or pyrimidine precursors of the nucleic acids. These agents have ...
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In the current study, phylogenetic analysis and molecular evolution of the mammalian’s Leptin was investigated. Data was achieved and aligned by searching its genome database, while all examined mammals contained only a single copy of the Leptin. The nucleotide substitution rate of the sequences and molecular evolution of the Leptin were calculated by maximum likelihood and neighbor-joinin...
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ورودعنوان ژورنال:
- Cancer research
دوره 10 3 شماره
صفحات -
تاریخ انتشار 1950